ATRIA Bleeding Risk Score
The ATRIA study sought to develop a risk stratification score to predict warfarin-associated hemorrhage. Included patients from the Kaiser Permanente of Northern California hospital system with non-valvular, non-transient atrial fibrillation via their ICD-9 codes and then followed up for a period of six to seven years. Patients randomly divided into split-sample “derivation” and “validation” cohorts, in a 2:1 ratio, respectively. The study sought to identify risk factors for patients with major hemorrhage, defined as fatal, requiring transfusion of ≥ 2 units pRBCs, or hemorrhage into critical anatomic site (intracranial, retroperitoneal, etc). Five variables were derived after statistical analysis and then weighed based on degree of effect. Scoring system consisted of five criteria, each of which was worth 1, 2, or 3 points. Study used ≤ 3 points to define low probability group (<1%) for major hemorrhage, 4 points for immediate (2.6%) and 5-10 points for high (5.8%). Points to keep in mind: Patients at risk for major hemorrhage, e.g. those with past intracranial bleeds, were likely already pre-excluded by clinicians and thus not included in the study
Details Formula Study characteristics Files & References
Model author
Model ID
155
Version
1.4
Revision date
2016-04-27
Specialty
MeSH terms
  • Atrial Fibrillation
  • Warfarin
  • Model type
    Linear model (Calculation)
    Status
    public
    Rating
    No rating criteria met
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    Formula
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    Condition Formula

    Additional information

    No additional information available

    Study Population

    Total population size: 0

    Additional characteristics

    No additional characteristics defined

    Related files

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    Supporting Publications

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    ATRIA Bleeding Risk Score
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    ATRIA Bleeding Risk Score

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    Outcome stratification

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    Result interpretation

    Determines bleeding risk for patients on warfarin.

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    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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