Details on development, validation and performance are available in:
Development and external validation of a new prognostic model for metastatic clear cell renal cell carcinoma: a preregistered analysis using data from randomised clinical trials in the checkpoint inhibitor era
Richters et al. Lancet Oncol 2026 (doi: 10.1016/S1470-2045(26)00338-4)
(Discrimination metrics below.)
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Classification into three prognostic groups:
0-40%: CPI2 favorable prognosis
40-57%: CPI2 intermediate prognosis
57-100%: CPI2 poor prognosis
Discrimination of the CPI2 score in external validation (Uno's C-index):
0.79 at 12 months
0.74 at 36 months
0.69 at 60 months
Discrimination of the CPI2 classification in external validation (Uno's C-index):
0.74 at 12 months
0.72 at 36 months
0.65 at 60 months
This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.
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