External validation of the Briganti 2012 nomogram in Dutch patients
Validation cohort contains patients from three dutch databases, the CWZ hospital in Nijmegen with 252 patients, the ZGT hospital in Hengelo with 108 patients and the Prozib database containing 581 patients. Prozib data contains data from all dutch hospitals providing prostate cancer care. After combining the three databases, 7 duplicate patients were removed, summing to a total of 934 patients eligible for validation. 
Validation author
Revision date
2018-06-26
MeSH terms
  • Cancer of Prostate
  • Lymph Node Dissection
  • Nomograms
  • Lymphadenectomy
  • Lymphatic Metastasis
  • Status
    public
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    Details

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    Supporting Publications

    No supporting publications available

    Discrimination

    C-index: 0.7603 | 95% CI: 0.7275 - 0.7931
    ROC Plot:

    Calibration

    Regression coefficient: 0.6557 | Intercept: 0.09
    Calibration plot:

    Histogram

    Rows included: 934
    Comparison
    Original study population: 588
    Validation study population: 934

    Categorical characteristics

    Name Subset / Group Nr. of patients Validation P-Value
    Clinical stage T1 373 262 0.0005
    T2 184 471
    T3 31 284
    Primary Gleason Grade ≤3 488 485 < 0.0001
    ≥4 100 543
    Secondary Gleason Grade ≤3 406 309 < 0.0001
    ≥4 182 718
    Pathologic stage pT2 431 Not available
    pT3a 97
    pT3b 58
    pT4 2
    Pathologic Gleason Score 2-6 223 Not available
    7 282
    8-10 63
    Missing 20

    Continuous characteristics

    Name LL Q1 Median Q3 UL Unit
    Original
    Validation
    Age
    60.3
    63
    65.9
    67
    70.4
    71

    Year Invalid Input
    Original
    Validation
    PSA level
    4.8
    7.2
    6.3
    12
    8.9
    26.2

    ng/ml Invalid Input
    Original
    Validation
    No. of cores taken
    13
    9
    16.5
    10
    24
    12

    Cores Invalid Input
    Original
    Validation
    No of positive cores
    3
    4
    6
    5
    10
    8

    Cores Invalid Input
    Original
    Validation
    Percentage of positive cores
    16.7
    35.5
    60.8

    % Invalid Input
    Original
    Validation
    No. of removed and examined lymph nodes
    15
    13
    19
    16
    25
    21

    Positive lymph nodes Invalid Input
    Original
    Validation
    No. of positive lymph nodes in patients with LN1
    1
    2
    3

    Positive lymph nodes Invalid Input
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    Related validations
    ProZIB -- Briganti 2012

    Validation cohort size: 581

    C-Index: 0.75 | 95% CI: 0.7046 - 0.7889

    Validation author: T. A. Hueting

    Revision date: 2017-06-14

    ROC Plot
    Calibration plot
    ZGT -- Briganti 2012

    Validation cohort size: 108

    C-Index: 0.70 | 95% CI: 0.6017 - 0.8053

    Validation author: T. A. Hueting

    Revision date: 2017-06-14

    ROC Plot
    Calibration plot
    CWZ Validation -- Briganti 2012

    Validation cohort size: 252

    C-Index: 0.79 | 95% CI: 0.7234 - 0.8592

    Validation author: T. A. Hueting

    Revision date: 2017-06-14

    ROC Plot
    Calibration plot