External validation of the Briganti 2012 nomogram in Dutch patients
Validation cohort contains patients from three dutch databases, the CWZ hospital in Nijmegen with 252 patients, the ZGT hospital in Hengelo with 108 patients and the Prozib database containing 581 patients. Prozib data contains data from all dutch hospitals providing prostate cancer care. After combining the three databases, 7 duplicate patients were removed, summing to a total of 934 patients eligible for validation. 
Research authors: None
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Discrimination

Rows included 934
C-index 0.76 | 95% CI: 0.7275 - 0.7931 ROC
Brier score 0.178
Scaled Brier score Not specified

Classification plot

Not specified

Calibration

Regression coefficient 0.656
Intercept 0.09
Hosmer-Lemeshow GOF < 0.001
 

Calibration plot

Histogram

Decision curve

Comparison
Original study population: 588
Validation study population: 934

Categorical characteristics

Name Subset / Group Nr. of patients Validation P-Value
Clinical stage T1 373 262 0.0005
T2 184 471
T3 31 284
Primary Gleason Grade ≤3 488 485 < 0.0001
≥4 100 543
Secondary Gleason Grade ≤3 406 309 < 0.0001
≥4 182 718
Pathologic stage pT2 431 Not available
pT3a 97
pT3b 58
pT4 2
Pathologic Gleason Score 2-6 223 Not available
7 282
8-10 63
Missing 20

Continuous characteristics

Name LL Q1 Median Q3 UL Unit
Original Validation Age
60.3
63
65.9
67
70.4
71

Year Invalid Input
Original Validation PSA level
4.8
7.2
6.3
12
8.9
26.2

ng/ml Invalid Input
Original Validation No. of cores taken
13
9
16.5
10
24
12

Cores Invalid Input
Original Validation No of positive cores
3
4
6
5
10
8

Cores Invalid Input
Original Validation Percentage of positive cores
16.7
35.5
60.8

% Invalid Input
Original Validation No. of removed and examined lymph nodes
15
13
19
16
25
21

Positive lymph nodes Invalid Input
Original Validation No. of positive lymph nodes in patients with LN1
1
2
3

Positive lymph nodes Invalid Input
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