Validation of Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer
This study aims to externally validate the underlying model in an independent cohort (N=250). Hereto, patients aged at least 65 years with a solid tumor, fluent in English, and who were scheduled to receive a new chemotherapy regimen were recruited from eight institutions.
Research authors: Hurria A, Mohile S, Gajra A, Klepin H, Muss H, Chapman A, Feng T, Smith D, Sun C, De Glas N, Cohen HJ, Katheria V, Doan C, Zavala L, Levi A, Akiba C, and Tew WP.
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Discrimination

Rows included 0
C-index 0.65 ROC
Brier score Not specified
Scaled Brier score Not specified

Classification plot

Not specified

Calibration

Regression coefficient 0
Intercept 0
Hosmer-Lemeshow GOF Not specified
 

Calibration plot

Histogram

Not specified

Decision curve

Not specified
Comparison
Original study population: 500
Validation study population: 250

Categorical characteristics

Name Subset / Group Nr. of patients Validation P-Value
Age 65-69 175 86 0.7066
70-74 127 67
75-79 105 60
80-84 73 30
85-91 20 7
Cancer type Breast 57 59 0.0005
Lung 143 64
Gastrointestinal 135 68
Gynecologic 87 18
Genitourinary 50 30
Other 28 11
Cancer stage Stage I 23 10 0.057
Stage II 59 40
Stage III 109 68
Stage IV/extensive 307 129
Limited 2 3
Educational level Less than high school 18 14 0.5147
High school graduate 175 82
Associate/bachelor's degree 202 109
Advanced degree 104 45
Missing 1 0
Marital status Married 306 Not available
Widowed 113
Single 16
Separated/divorced 65
Employment status Full or part-time 83 Not available
Retired, homemaker, unemployed 395
Disabled, medical leave 21
Missing 1
Household composition Lives alone 106 Not available
Lives with spouse, partner, or child 390
Missing 4
Race/ethnicity White 426 206 0.008
Black 42 20
Asian 26 10
Other 6 14
Sex Female 281 138 0.8152
Male 219 112

Continuous characteristics

Name Mean SD Unit Plot
Original Validation Age 73
73
6.2
6
years
Original Validation Instrumental activities of daily living scale 12.9
13
1.8
2
points
Original Validation MOS Physical health scale 68.5
64.9
26
27
points
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