Validation of Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer
This study aims to externally validate the underlying model in an independent cohort (N=250). Hereto, patients aged at least 65 years with a solid tumor, fluent in English, and who were scheduled to receive a new chemotherapy regimen were recruited from eight institutions.
Validation study authors: Hurria A, Mohile S, Gajra A, Klepin H, Muss H, Chapman A, Feng T, Smith D, Sun C, De Glas N, Cohen HJ, Katheria V, Doan C, Zavala L, Levi A, Akiba C, and Tew WP.
Validation author
Revision date
2017-05-27
MeSH terms
  • Chemotherapy
  • Toxicity, Drug
  • Assessment, Geriatric
  • Validation Studies
  • Status
    public
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    Discrimination

    Rows included 0
    C-index 0.65
    Brier score Not specified
    Scaled Brier score Not specified
    ROC Plot:

    Calibration

    Regression coefficient Not specified
    Intercept Not specified
    Hosmer-Lemeshow GOF < 0.001
     
    Calibration plot:

    Histogram

    Not specified

    Decision curve

    Not specified
    Comparison
    Original study population: 500
    Validation study population: 250

    Categorical characteristics

    Name Subset / Group Nr. of patients Validation P-Value
    Age 65-69 175 86 0.7066
    70-74 127 67
    75-79 105 60
    80-84 73 30
    85-91 20 7
    Cancer type Breast 57 59 0.0005
    Lung 143 64
    Gastrointestinal 135 68
    Gynecologic 87 18
    Genitourinary 50 30
    Other 28 11
    Cancer stage Stage I 23 10 0.057
    Stage II 59 40
    Stage III 109 68
    Stage IV/extensive 307 129
    Limited 2 3
    Educational level Less than high school 18 14 0.5147
    High school graduate 175 82
    Associate/bachelor's degree 202 109
    Advanced degree 104 45
    Missing 1 0
    Marital status Married 306 Not available
    Widowed 113
    Single 16
    Separated/divorced 65
    Employment status Full or part-time 83 Not available
    Retired, homemaker, unemployed 395
    Disabled, medical leave 21
    Missing 1
    Household composition Lives alone 106 Not available
    Lives with spouse, partner, or child 390
    Missing 4
    Race/ethnicity White 426 206 0.008
    Black 42 20
    Asian 26 10
    Other 6 14
    Sex Female 281 138 0.8152
    Male 219 112

    Continuous characteristics

    Name Mean SD Unit Plot
    Original
    Validation
    Age 73
    73
    6.2
    6
    years
    Original
    Validation
    Instrumental activities of daily living scale 12.9
    13
    1.8
    2
    points
    Original
    Validation
    MOS Physical health scale 68.5
    64.9
    26
    27
    points
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