Probability of anaphylaxis in patients with systemic mastocytosis - Evidencio
Probability of anaphylaxis in patients with systemic mastocytosis
Anaphylaxis is a common feature in patients with mastocytosis. However, not all patients with mastocytosis experience anaphylaxis. A risk analysis model for anaphylaxis was translated into a clinical scoring system.
Research authors: Gülen T, Ljung C, Nilsson G, and Akin C.
Version: 1.18
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  • Immunology
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Total anaphylaxis risk score: points

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How this model should be used:
This risk assessment tool may provide a simple method of identifying and alerting patients with mastocytosis at high risk of anaphylaxis who would benefit from self-injectable epinephrine.

Model performance:
In the underlying study by Gülen et al (2017)1, a sensitivity of 86% (95% CI: 74.6 - 93.1%) and a specificity of 54% (95% CI: 41.8 - 65.4%) was observed in the development cohort (n=122). The corresponding postive predictive value (PPV) and negative predictive value (NPV) were 60.3% (95% CI: 49.2 - 70.7%) and 81.8% (95% CI: 68.6 - 91.2%), respectively. 

Source:

  1. Gülen T et al. Risk Factor Analysis of Anaphylactic Reactions in Patients With Systemic Mastocytosis. J Allergy Clin Immunol Pract. (2017).

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This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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