Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAAC - Evidencio
Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI) algorithm

To start, please evaluate if the patient experienced symptoms suggestive of an immediate or delayed type reaction.


Overview clinical criteria for anaphylaxis:

Anaphylaxis defined as rapid (<6 h) simultaneous involvement of ≥2 organ systems following exposure to culprit drug:

  1. Skin and/or mucosal tissue: rash, pruritus, erythema, hives/urticaria, swelling of the face, lips, tongue, or uvula.

  2. Respiratory symptoms: dyspnea, wheeze, bronchospasm,, stridor, hypoxemia, persistent cough and/or throat clearing.

  3. Severe gastrointestinal symptoms: severe crampy abdominal pain with diarrhea, repetitive vomiting.

  4. Cardiovascular symptoms: hypotension: systolic blood pressure <90 mm Hg or a decrease of >30% from baseline.


Overview severe delayed type reactions (SCAR):

Overview of severe adverse reactions, including: AGEP: Acute Generalized Exanthematous Pustulosis; DRESS: Drug Reaction with Eosonophilia and Systemic Symptoms; SJS: Stevens-Johnson Syndrome; TEN: Toxic Epidermal Necrolysis.


Research authors: Philip Hei Li, Bernard Yu-Hor Thong, Ruby Pawanker, Chandima Jeewandara, et al.
Version: 1.0
  • Public
  • Allergology
  • {{ modelType }}
  • Details
  • Validate algorithm
  • Save input
  • Load input
Display
Units

{{section.title}}

Calculate the result

Set more parameters to perform the calculation

Number of high(er) risk features: (APAACI algorithm)

{{ resultSubheader }}
{{ $t('download_result_availability') }}
{{ chart.title }}
Result interval {{ additionalResult.min }} to {{ additionalResult.max }}

Conditional information

Reference:

  1. Li PH, Thong BY, Pawankar R, Jeewandara C, Lobo RCM, Kang HR, et al. APAAACI clinical pathway on direct provocation testing for penicillin allergy delabeling. Asia Pac Allergy. 2023;13(4):142-147. doi: 10.5415/apallergy.0000000000000122.

{{ file.classification }}
PRO
Note
Notes are only visible in the result download and will not be saved by Evidencio

This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

Underlying algorithms Part of
Comments
Comment
Please enter a comment
Comments are visible to anyone

Algorithm feedback

No feedback yet 1 Comment {{ model.comments.length }} Comments
On {{ comment.created_at }} {{ comment.user.username }} a no longer registered author wrote:
{{ comment.content }}
logo

Please sign in to enable Evidencio print features

In order to use the Evidencio print features, you need to be logged in.
If you don't have an Evidencio Community Account you can create your free personal account at:

https://www.evidencio.com/registration

Printed results - Examples {{ new Date().toLocaleString() }}


Evidencio Community Account Benefits


With an Evidencio Community account you can:

  • Create and publish your own prediction algorithms.
  • Share your prediction algorithms with your colleagues, research group, organization or the world.
  • Review and provide feedback on algorithms that have been shared with you.
  • Validate your algorithms and validate algorithms from other users.
  • Find algorithms based on Title, Keyword, Author, Institute, or MeSH classification.
  • Use and save prediction algorithms and their data.
  • Use patient specific protocols and guidelines based on sequential algorithms and decision trees.
  • Stay up-to-date with new algorithms in your field as they are published.
  • Create your own lists of favorite algorithms and topics.

A personal Evidencio account is free, with no strings attached!
Join us and help create clarity, transparency, and efficiency in the creation, validation, and use of medical prediction algorithms.


Disclaimer: Calculations alone should never dictate patient care, and are no substitute for professional judgement.
Evidencio v3.36 © 2015 - 2025 Evidencio. All Rights Reserved