Calculating drug steady state achieved (days)
The steady state of drug intake regards a constant mean concentration of a drug in which the elimination and absorption of the drug is equal. The time to achieve steady state is relying on the half-life of the drug. This formula can be used to quickly assess how long it would take to achieve steady state.

Mostly, 4-5 half-lives are used to achieve clinical steady state
Details Formula Study characteristics Files & References
Model author
Model ID
1134
Version
1.4
Revision date
2018-02-19
MeSH terms
  • Half Life
  • Oral Drug Administration
  • Model type
    Custom model (Calculation)
    Status
    public
    Rating
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    Time to achieve steady state is
    ...
    days

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    Time to achieve steady state is days

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    Result interpretation

    If the time to achieve steady state is longer than desired, an initial loading dose of a drug can be administered to reach the desired blood concentration quickly.
    Note: The loading dose is based on the volume of distribution and the maintenance dose is based on the half-life of the drug administered. 

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    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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