Tumour-positive margins after breast-conserving surgery (BCS) for breast cancer increase local recurrence risk and require additional therapy.
In the Netherlands, in cases of incomplete surgical resections, we make a distinction between 'focally positive' (≤4 mm tumour margin involvement) and ‘extensively positive’ (>4 mm tumour margin involvement or multiple focally positive foci) surgical margins.
This prediction model incorporates all tumour-positive margins (both focally positive and extensively positive) and is based on 109.475 included patients undergoing BCS for non-metastatic breast cancer in the Netherlands from 2009-2022, selected from the Netherlands Cancer Registry. As the aim of our study was to assess potential impact of intraoperative margin assessment innovations, patients with a pathological complete response (pCR) were excluded and are not included in the prediction model.
The tool still requires external validation and is not yet suitable for use in clinical decision-making.
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