Glomerular Filtration Rate (GFR) - Creatinine-Cystatin C equation
Estimates of glomerular filtration rate (GFR) that are based on serum creatinine are routinely used; however, they are imprecise, potentially leading to the overdiagnosis of chronic kidney disease. Cystatin C is an alternative filtration marker for estimating GFR.
Research authors: Lesley A. Inker, Christopher H. Schmid, Hocine Tighiouart, John H. Eckfeldt, Harold I. Feldman, Tom Greene, John W. Kusek, Jane Manzi, Frederick Van Lente, Yaping Lucy Zhang, Josef Coresh, Andrew S. Levey
Details Custom formula Study characteristics Files & References
★★★
Model author
Model ID
1183
Version
1.4
Revision date
2018-11-26
MeSH terms
  • Glomerular Filtration Rate
  • Cystatin C
  • Model type
    Custom model (Conditional)
    Status
    public
    Rating
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    Condition Formula

    Additional information

    No additional information available

    Study Population

    Total population size: 5352
    Males: {{ model.numberOfMales }}
    Females: {{ model.numberOfFemales }}

    Continuous characteristics

    Name Mean SD Unit
    Age 47 15 Year
    BMI 28 6 kg/m2
    Weight 83 20 kg
    Height 171 10 cm
    Body surface area 1.94 0.24 m2
    Serum cystatin C 1.4 0.7 mg/liter
    Serum creatinine 1.6 0.9 mg/dl
    Mean measured GFR 68 39 ml/min/1.73m2

    Categorical characteristics

    Name Subset / Group Nr. of patients
    Age group <40 2008
    40-65 2625
    >65 719
    Race Black 2123
    Other 3229
    Diabetes No 3626
    Yes 1726
    BMI <20 214
    20-24 1585
    25-30 1881
    >30 1671
    Measured GFR (ml/min/1.73m2) <15 160
    15-29 785
    30-59 1765
    60-89 1105
    90-119 862
    >120 675

    Estimated Glomerular Filtration Rate is:
    ...
    mL/min/1.73m2

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    Result
    Note
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    Estimated Glomerular Filtration Rate is: mL/min/1.73m2

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    Outcome stratification

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    Conditional information

    Result interpretation

    The GFR was calculated using the creatinine-cystatin C equation, the GFR can be estimated using other formulas such as the cystatin C equation, the Cockcroft-Gault equation, or the MDRD equation. 

    The glomerular filtration rate should only be assessed in a steady state condition for reliable results. 

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    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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