Creatinine clearance based on 24-hour urine collection
Calculates the creatinine clearance in ml/min as a measure of renal function. To use this model, both the serum creatinine and the amount of creatinine in the 24-hour urine sample has to be known. 
Research authors: None
  • Internal medicine
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Calculated creatinine clearance ml/min

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Background: 
Creatinine clearance can be used as an estimate for the glomerular filtration rate (GFR).1 Creatinine is produced by the body at a fairly constant rate, depending on the amount of muscle mass present. It is mainly filtered passively in the kidney, but a small amount is actively secrated. 

Evaluation
Creatinine clearance is often estimated based on the serum creatinine in the blood or in 24-hour urine. Shorter periods of collection are possible, but often lead to less acurate results. This may be partly explained by the fact that shorter periods of collection result in a relatively high percentage of urine remaining in the bladder compared to the total volume of collected urine. Also, the secration of creatinine varies during the day.2 

Reference values: 
The creatinine clearance in healthy adults is 80-120 ml/min.

Sources: 

  1. Doolan PD, Alpen EL, Theil GB. A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med 1962; 32:65.
  2. Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 1992; 38:1933.

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Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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