Creatinine clearance based on 24-hour urine collection
Calculates the creatinine clearance in ml/min as a measure of renal function. To use this model, both the serum creatinine and the amount of creatinine in the 24-hour urine sample has to be known. 
Details Formula Study characteristics Files & References
Model author
Model ID
Revision date
MeSH terms
  • Kidney
  • Kidney Failure
  • Creatinine
  • Urine
  • Renal Insufficiency
  • Model type
    Custom model (Calculation)
    No rating criteria met

    Additional information

    As far as known, there is no known specific patient population used to develop the current calculator.


    Study Population

    Total population size: 0

    Additional characteristics

    No additional characteristics defined
    Creatinine clearance based on 24-hour urine collection
    Refer to Intended Use for instructions before use
    Evidencio B.V., Irenesingel 19, 7481 GJ, Haaksbergen, the Netherlands

    Related files

    No related files available

    Supporting Publications

    Calculated creatinine clearance

    {{ resultSubheader }}

    {{ model.survival.PITTitle }}

    {{ model.survival.YNETitle }}

    Notes are only visible in the result download and will not be saved by Evidencio

    Calculated creatinine clearance ml/min

    {{ resultSubheader }}
    {{ chart.title }}

    Outcome stratification

    Result interval {{ additionalResult.min }} to {{ additionalResult.max }}

    Conditional information

    Result interpretation

    Creatinine clearance can be used as an estimate for the glomerular filtration rate (GFR).1 Creatinine is produced by the body at a fairly constant rate, depending on the amount of muscle mass present. It is mainly filtered passively in the kidney, but a small amount is actively secrated. 

    Creatinine clearance is often estimated based on the serum creatinine in the blood or in 24-hour urine. Shorter periods of collection are possible, but often lead to less acurate results. This may be partly explained by the fact that shorter periods of collection result in a relatively high percentage of urine remaining in the bladder compared to the total volume of collected urine. Also, the secration of creatinine varies during the day.2 

    Reference values: 
    The creatinine clearance in healthy adults is 80-120 ml/min.


    1. Doolan PD, Alpen EL, Theil GB. A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med 1962; 32:65.
    2. Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 1992; 38:1933.

    {{ file.classification }}

    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

    Please enter a comment of rating
    Comments are visible to anyone

    Model feedback

    No feedback yet 1 Comment {{ model.comments.length }} Comments
    Not rated | On {{ comment.created_at }} {{ comment.user.username }} a no longer registered author wrote:

    Please sign in to enable Evidencio print features

    In order to use the Evidencio print features, you need to be logged in.
    If you don't have an Evidencio Community Account you can create your free personal account at:

    Printed results - Examples {{ new Date().toLocaleString() }}

    Evidencio Community Account Benefits

    With an Evidencio Community account you can:

    • Create and publish your own prediction models.
    • Share your prediction models with your colleagues, research group, organization or the world.
    • Review and provide feedback on models that have been shared with you.
    • Validate your models and validate models from other users.
    • Find models based on Title, Keyword, Author, Institute, or MeSH classification.
    • Use and save prediction models and their data.
    • Use patient specific protocols and guidelines based on sequential models and decision trees.
    • Stay up-to-date with new models in your field as they are published.
    • Create your own lists of favorite models and topics.
    A personal Evidencio account is free, with no strings attached! Join us and help create clarity, transparency, and efficiency in the creation, validation, and use of medical prediction models.

    Disclaimer: Calculations alone should never dictate patient care, and are no substitute for professional judgement.