Creatinine clearance based on 24-hour urine collection
Calculates the creatinine clearance in ml/min as a measure of renal function. To use this model, both the serum creatinine and the amount of creatinine in the 24-hour urine sample has to be known. 
Details Custom formula Study characteristics Files & References
Model author
Model ID
1359
Version
1.2
Revision date
2018-05-31
MeSH terms
  • Kidney
  • Kidney Failure
  • Creatinine
  • Urine
  • Renal Insufficiency
  • Model type
    Custom model (Calculation)
    Status
    public
    Rating
    No rating criteria met
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    Formula

    Additional information

    As far as known, there is no known specific patient population used to develop the current calculator.

     

    Study Population

    Total population size: 0

    Additional characteristics

    No additional characteristics defined

    Related files

    No related files available

    Supporting Publications

    Calculated creatinine clearance
    ...
    ml/min

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    Calculated creatinine clearance ml/min

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    Outcome stratification

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    Conditional information

    Result interpretation

    Background: 
    Creatinine clearance can be used as an estimate for the glomerular filtration rate (GFR).1 Creatinine is produced by the body at a fairly constant rate, depending on the amount of muscle mass present. It is mainly filtered passively in the kidney, but a small amount is actively secrated. 

    Evaluation
    Creatinine clearance is often estimated based on the serum creatinine in the blood or in 24-hour urine. Shorter periods of collection are possible, but often lead to less acurate results. This may be partly explained by the fact that shorter periods of collection result in a relatively high percentage of urine remaining in the bladder compared to the total volume of collected urine. Also, the secration of creatinine varies during the day.2 

    Reference values: 
    The creatinine clearance in healthy adults is 80-120 ml/min.

    Sources: 

    1. Doolan PD, Alpen EL, Theil GB. A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med 1962; 32:65.
    2. Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 1992; 38:1933.

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    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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