Diagnosis of non-obstructive coronary artery and multi-vessel disease - Two vessel disease
The proposed ordinal diagnostic risk model, employing routinely obtainable variables, allows distinguishing the extent of Coronary Artery Disease (CAD) and can especially discriminate between non-obstructive stenosis and multi-vessel disease in the Coronary Artery disease Risk Determination In Innsbruck by diaGnostic ANgiography (CARDIIGAN) patients. This can help to decide on treatment strategy and thereby reduce the number of unnecessary angiographies.
Research authors: Michael Edlinger, Jakob Dörler, Hanno Ulmer, Maria Wanitschek, Ewout W. Steyerberg, Hannes F. Alber, Ben van Calster
Details Formula Study characteristics Files & References
Model author
Model ID
Revision date
MeSH terms
  • Coronary Artery
  • Coronary Artery Disease
  • Model type
    Custom model (Calculation)

    Additional information

    A total of 4888 patients from the Coronary Artery disease Risk Determination In Innsbruck by diaGnostic ANgiography (CARDIIGAN) cohort were included. An ordinal regression model was applied to estimate the probabilities of five incrementally disease categories: no CAD, non-obstructive stenosis, and one-, two- and three-vessel disease. 11 predictors were included in the model: age, sex, chest pain, diabetes, hypertension, dyslipidaemia, smoking, HDL and LDL cholesterol, fibrinogen, and C-reactive protein. Bootstrapping was used to validate model performance (discrimination and calibration).

    Study Population

    Total population size: 4888
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    Females: {{ model.numberOfFemales }}

    Continuous characteristics

    Name Mean SD Unit
    Age 64.2 10.4 years

    Categorical characteristics

    Name Subset / Group Nr. of patients
    Disease No coronary artery disease 1381
    Non-obsructive stenosis 1606
    One-vessel disease 997
    Two-vessel disease 475
    Three vessel disease 429
    Chest pain No 1902
    Yes 2986
    Diabetes mellitus No 4131
    Yes 757
    Hypertension No 1159
    Yes 3729
    Dyslipidaemia No 1773
    Yes 3115

    Related files

    Calculated probability for two-vessel disease is:

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    Calculated probability for two-vessel disease is: %

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    Outcome stratification

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    Conditional information

    Result interpretation

    The current model was not yet externally validated and should therefore not be used to influence clinical decision making. 

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    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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