Risk score for detecting insignificant prostate cancer in unscreened patient cohorts
This risk score was developed to differentiate between insignificant and significant prostate cancer in patients with Gleason 3+3 or lower prostate cancer in the preoperative setting. It allows users to select the desired sensitivity and specificity levels for detecting insignificant prostate cancer using two different cut-offs:
 
  • Cut-off 1: By selecting this cut-off value the calculator will have a sensitivity and specificity of 90% and 41% in detecting insignificant cancer, respectively. This setting is aimed at reducing the risk of over-treatment as much as possible (improved detection of true positive results).
 
  • Cut-off 2: By selecting this cut-off value the calculator will have a sensitivity and specificity of 38% and 90% in detecting insignificant cancer, respectively. This setting is aimed at reducing the risk of missing a significant PCa as much as possible (improved detection of true negative results).
Research authors: Dutto L, Ahmad A, Urbanova K, Wagner C, Schuette A, Addali M, Kelly JD, Shridhar A, Nathan S, Briggs TP, Witt JH, Shaw G
Version: 1.113
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Relative odds of having insignificant PCa, compared to study population:

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This model is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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