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 as a function of uncorrected QT-interval (Joy et al, 2011).png)
Probability of torsades de pointes (TdP) based on uncorrected QT interval: ...
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Probability of torsades de pointes (TdP) based on uncorrected QT interval:
Outcome stratification
Conditional information
Result interpretation
Context information:
Measures of the magnitude of (uncorrected) QT interval predicted the risk of TdP significantly better than dose, heart rate, or the mere presence of a prolonged QT. Moreover, the magnitude of the QT prolongation was a better predictor of TdP than the mere presence or absence of an abnormal QT, highlighting the problematic nature of using a single cutoff value for risk assessment.
Source:
Joy JP, Coulter CV, Duffull SB, Isbister GK. Prediction of torsade de pointes from the QT interval: analysis of a case series of amisulpride overdoses. Clin Pharmacol Ther. 2011;90(2):243-5.
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