Corrected QT interval and corresponding risk of torsades de pointes in drug-induced QT prolongation
This risk tool accurately predicts torsade de pointes (TdP) risk for drug-induced QT prolongation, allowing users to select the desired sensitivity and specificity for detecting torsades des points using different cut-offs:
 
  • Cut-off 1 (Bazett's QTc = 500 ms): By selecting this cut-off value, the calculator will have a sensitivity and specificity of 93.8% and 97.2% in detecting torsades des pointes, respectively. This setting aims at reducing the probability of unnecessary cardiac monitoring as much as possible.
 
  • Cut-off 2 (Bazett's QTc = 440 ms): By selecting this cut-off value, the calculator will have a sensitivity and specificity of 98.5% and 66.7% in detecting torsades de points, respectively. This setting aims at reducing the risk of missing torsades des points as much as possible.
Research authors: Chan A, Isbister GK, Kirkpatrick CM, and Dufful SB.
Version: 1.39
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Corrected QT interval based on Bazett's formula: ms

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Context information:
The aim of the underlying study was to evaluate the performance of the QT nomogram in assessing the risk of TdP, comparing QT-heart rate combinations for known cases of drug-induced TdP cases to those of a negative control group with normal QT-HR values.

Source:
Chan A, Isbister GK, Kirkpatrick CM, Dufful SB. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100(10):609-15.

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This model is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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