Corrected QT interval and corresponding risk of torsades de pointes in drug - Evidencio
Corrected QT interval and corresponding risk of torsades de pointes in drug-induced QT prolongation
This risk tool accurately predicts torsade de pointes (TdP) risk for drug-induced QT prolongation, allowing users to select the desired sensitivity and specificity for detecting torsades des points using different cut-offs:
 
  • Cut-off 1 (Bazett's QTc = 500 ms): By selecting this cut-off value, the calculator will have a sensitivity and specificity of 93.8% and 97.2% in detecting torsades des pointes, respectively. This setting aims at reducing the probability of unnecessary cardiac monitoring as much as possible.
 
  • Cut-off 2 (Bazett's QTc = 440 ms): By selecting this cut-off value, the calculator will have a sensitivity and specificity of 98.5% and 66.7% in detecting torsades de points, respectively. This setting aims at reducing the risk of missing torsades des points as much as possible.
Autores de la investigación: Chan A, Isbister GK, Kirkpatrick CM, and Dufful SB.
Versión: 1.39
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Corrected QT interval based on Bazett's formula: ms

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Context information:
The aim of the underlying study was to evaluate the performance of the QT nomogram in assessing the risk of TdP, comparing QT-heart rate combinations for known cases of drug-induced TdP cases to those of a negative control group with normal QT-HR values.

Source:
Chan A, Isbister GK, Kirkpatrick CM, Dufful SB. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100(10):609-15.

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