Individual risk for pancreatic fistula after pancreatoduodenectomy - multiv - Evidencio
Individual risk for pancreatic fistula after pancreatoduodenectomy - multivariate logistic regression
This model estimates the risk of pancreatic fistula after pancreatoduodenectomy based on the original predictor coefficients.
Research authors: Callery MP, Pratt WB, Kent TS, Chaikof EL, Vollmer CM Jr.
Version: 1.18
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Calculated risk for postoperative pancreatic fistula:

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Important note:
This model was newly developed based on the original predictor coefficients as reported by Callery et al (2013). Before application in a clinical setting, this model needs to be validated in independent datasets.  

Original study population:
In the modeling group (N=233) of the original study (Callery et al, 2013), clinically relevant postoperative pancreatic fistulas occurred in 13% of the patients. Independent logistic regression analysis revealed that patients with pancreatic duct diameters measuring 3 mm or smaller (OR 2.78, 95% CI 1.22 to 6.35, p = 0.015), or those with ampullary, duodenal, cystic, or islet cell pathology (OR 2.98, 95% CI 1.36 to 6.54, p = 0.007) were nearly 3 times as likely to develop clinically relevant postoperative pancreatic fistula (CR-POPF). Soft pancreatic parenchyma resulted in a 5-fold increase in the likelihood of developing CR-POPF (OR 5.02, 95% CI 1.97 to 12.81, p < 0.001). Intraoperative blood loss in excess of 1,000 mL had the most significant impact, predisposing patients to nearly a 6-fold increase in fistula development (OR 5.60, 95% CI 1.65 to 18.98, p = 0.006).  

Reference:
  1. Callery MP, Pratt WB, Kent TS, Chaikof EL, Vollmer CM. A prospectively validated risk score accurately predicts pancreatic fistula after pancreatoduodenectomy. J Am Coll Surg. 2013; 216(1):1–14.   

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This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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