A multicentre cohort study of serum and peritoneal biomarkers to predict an - Evidencio
A multicentre cohort study of serum and peritoneal biomarkers to predict anastomotic leakage after rectal cancer resection
This model predicts the individual risk for anastomotic leakage after rectal resection with systemic CRP and peritoneal MMP9 levels on postoperative day 3

(c-index = 0.78)
Research authors: C.L. Sparreboom, N. Komen, D. Rizopoulos, A.P. Verhaar, W.A. Dik, Z. Wu , H.L. van Westreenen, P.G. Doornebosch, J.W.T. Dekker, A.G. Menon, F. Daams, D. Lips, W.M.U. van Grevenstein, T.M. Karsten, Y. Bayon, M.P. Peppelenbosch, A.M. Wolthuis, A. D'Hoore, J.F. Lange
Version: 1.45
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The risk of anastomotic leakage after rectal resection

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This prospective multicenter cohort study provides a prediction model for anastomotic leakage after rectal resection including CRP and MMP9 on postoperative day 3. This nomogram calculates the individual risk for anastomotic leakage after rectal resection. Assessment of model discrimination yielded a concordance index of 0.78. In addition, this model obtained good calibration with a mean absolute error of 0.025. 

This tool should never replace clinical observations and should be interpreted in clinical context as with any other diagnostic tool.

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This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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