Prediction of seminal vesicle invasion including multiparametric MRI
The current model estimates the risk of prostatic cancer involving the seminal vesicles. Next to clinical characteristics, the model also incorporates SVI presence on multiparametric magnetic resonance imaging (mp-MRI). 
Research authors: Alberto Martini, Akriti Gupta, Shivaram Cumarasamy, Sara C Lewis, Kenneth G Haines III, Alberto Briganti, Francesco Montorsi, Ashutosh K Tewari
Version: 1.4
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The risk for seminal vesicle involvement is:

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The current model showed an area under the curve of 0.85 (95% CI: 0.818 - 0.911) on internal validation. Where SVI prediction on mpMRI alone showed an AUC of 0.59 (95% CI: 0.540 - 0.643). 

Decision curve analysis showed a benefit of applying the model in clinical practice with threshold probabilities ≤25%. 

Internal validation showed a slight miscalibration of predicted SVI probabilities >40%. However, it is highly unlikely that surgeons will attempt a conservative approach to the seminal vesicles if the risk of involvement is higher than 40%. 

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