Prediction of seminal vesicle invasion including multiparametric MRI
The current model estimates the risk of prostatic cancer involving the seminal vesicles. Next to clinical characteristics, the model also incorporates SVI presence on multiparametric magnetic resonance imaging (mp-MRI). 
Research authors: Alberto Martini, Akriti Gupta, Shivaram Cumarasamy, Sara C Lewis, Kenneth G Haines III, Alberto Briganti, Francesco Montorsi, Ashutosh K Tewari
Details Formula Study characteristics Files & References
Model author
Model ID
Revision date
MeSH terms
  • Prostate Cancer
  • Prostate Specific Antigen
  • Magnetic Resonance Imaging
  • Model type
    Logistic regression (Calculation)
    No Formula defined yet
    Condition Formula

    Additional information

    The final analysis encompassed 544 patients.who underwent robot-assisted radical prostatectomy at a single institution between October 2014 and May 2015. The data were retrospectively collected. All patients received a standardized mpMRI using 3T magnetic field strength and a pelvic phased-array coil.. When an mpMRI was carried out before prostate biopsy, two to four targeted biopsy cores were obtained in addition to systemic sampling. All biopsies were transrectal biopsy, no extra core was obtained in the case of lesion(s) in the seminal vesicle(s).

    Study Population

    Total population size: 544
    Males: {{ model.numberOfMales }}
    Females: {{ model.numberOfFemales }}

    Continuous characteristics

    Name LL Q1 Median Q3 UL Unit
    Age 56 62 67 years
    Preoperative PSA 4.3 5.5 7.9 ng/ml
    Max % core involvement 20 50 80 %

    Categorical characteristics

    Name Subset / Group Nr. of patients
    Clinical T stage T1c 357
    T2a 102
    T2b 45
    T2c 31
    T3 9
    Biopsy Gleason group 1 158
    2 215
    3 93
    4 56
    5 22
    Pathological stage T2 404
    T3a 89
    T3b 50
    Tx 1
    Pathologic Gleason grade group 1 71
    2 322
    3 110
    4 11
    5 29
    Unknown 1
    Seminal vesicle involvement No 480
    Yes 64

    Related files

    Supporting Publications

    The risk for seminal vesicle involvement is:

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    The risk for seminal vesicle involvement is:

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    Outcome stratification

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    Conditional information

    Result interpretation

    The current model showed an area under the curve of 0.85 (95% CI: 0.818 - 0.911) on internal validation. Where SVI prediction on mpMRI alone showed an AUC of 0.59 (95% CI: 0.540 - 0.643). 

    Decision curve analysis showed a benefit of applying the model in clinical practice with threshold probabilities ≤25%. 

    Internal validation showed a slight miscalibration of predicted SVI probabilities >40%. However, it is highly unlikely that surgeons will attempt a conservative approach to the seminal vesicles if the risk of involvement is higher than 40%. 

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    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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