Santeon mpMRI-based Nomogram to Predict Side-Specific Extraprostatic Extension
We developed a prediction model which can be used to accurately assess the likelihood of tumour extension outside the prostate. This tool can guide patient selection for safe nerve-sparing surgery.

Description of imput parameters:
PSA Density: most recent preoperative PSA level divided by prostate volume measured by TRUS or MRI
MRI (side-specific): no lesion (no lesion visible, PI-RADS <3), organ-confined (PI-RADS >2, but no EPE, EPE (lesion with reported EPE). *equivocal or uncertain EPE should be regarded as organ-confined
ISUP (side-specific): highest reported ISUP found on most recent preoperative biopsy
Research authors: Timo F.W. Soeterik, Harm H.E. van Melick, Lea M. Dijksman, Heidi Küsters-Vandevelde, Saskia Stomps, Ivo G. Schoots, Douwe H. Biesma, J.A. Witjes, Jean-Paul A. van Basten
Details Formula Study characteristics Files & References
Model author
Model ID
Revision date
MeSH terms
  • Prostatectomy
  • Model type
    Logistic regression (Calculation)
    No Formula defined yet
    Condition Formula

    Additional information

    Design, setting and participants: A retrospective analysis of 1,870 consecutive prostate cancer patients that underwent robot-assisted RP from 2014 to 2018 at three institutions.

    Outcome measurements and statistical analysis: Four multivariable logistic regression models included combinations of significant EPE predictors: PSA-density, biopsy ISUP grade, clinical and mpMRI T-stage, and percentage positive cores on systematic biopsy. Discrimination (area under the receiver operating curve [AUC]), calibration and net benefit were assessed.

    Study Population

    Total population size: 1870

    Categorical characteristics

    Name Subset / Group Nr. of patients
    Extraprostatic extension (EPE) at histopathology No EPE 1316
    EPE 458
    Santeon mpMRI-based Nomogram to Predict Side-Specific Extraprostatic Extension
    Refer to Intended Use for instructions before use
    Evidencio B.V., Irenesingel 19, 7481 GJ, Haaksbergen, the Netherlands

    Related files

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    Side-specific risk of EPE:

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    Side-specific risk of EPE:

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    Outcome stratification

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    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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