Glomerular filtration rate (GFR) - MDRD-formula
Estimates glomerular filtration rate according to the MDRD-formula (ml/min/1.73m2).
Research authors: Levey AS, Stevens LA, Schmid CH, Zhang Y, Castro AF, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J.
Details Formula Study characteristics Files & References
Model author
Model ID
Revision date
MeSH terms
  • Glomerular Filtration Rate
  • Kidney Function Tests
  • Model type
    Custom model (Calculation)

    Additional information

    Key inclusion criteria were measurement of GFR using exogenous filtration markers and ability to calibrate serum creatinine assay. Studies for development and internal validation of equations were restricted to those using urinary clearance of iothalamate. Studies for external validation included iothalamate and other filtration markers. Ten studies (6 research studies and 4 clinical populations) with a total of 8,254 participants were divided randomly into separate datasets for development (n=5,504) and internal validation (n=2,750). Sixteen other studies (6 research studies and 10 clinical populations) with a total of 3,896 participants were used for external validation.

    Study Population

    Total population size: 5504
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    Continuous characteristics

    Name Mean SD Unit
    Age 47 15 years
    Height 170 10 cm
    Body mass index (BMI) 28 6 kg/m2
    Bodey weight 82 20 kg
    Body surface area 1.93 0.20 m2
    Mean glomerular filtration rate 68 40 ml/min/1.73m2
    Serum creatinine level 146 106 umol/l
    Serum creatinine level 1.65 1.20 mg/dl

    Categorical characteristics

    Name Subset / Group Nr. of patients
    Race Black 1728
    Hispanic 247
    Asian 62
    White and other 3467
    Kidney donor Yes 694
    No 4810
    Transplant recipient 241 5263
    Diabetes mellitus Yes 1581
    No 3923
    Glomerular filtration rate (GFR) - MDRD-formula
    Refer to Intended Use for instructions before use
    Evidencio B.V., Irenesingel 19, 7481 GJ, Haaksbergen, the Netherlands

    Related files

    Estimated GFR:

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    Estimated GFR: mL/min/1.73m2

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    Outcome stratification

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    Conditional information

    Result interpretation

    This glomerular filtration rate (GFR) was calculated using the MDRD-formula. Additional formulas to calculate the GFR are available, e.g. the Cockcroft-Gault formula. 

    Note: The glomerular filtration rate should only be assessed in a steady state condition for reliable results. 

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    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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