Glomerular filtration rate (GFR) - Cockcroft & Gault formula
Calculates the estimated glomerular filtration rate based on the Cockcroft & Gault formula.
Research authors: Cockcroft DW, Gault MH.
Version: 1.23
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Estimated glomerular filtration rate: ml/min

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Although creatinine clearance may over-estimate GFR by 10-20%, it still remains the standard for drug dosing adjustments.

The Cockcroft-Gault equation1 should be based on body weight and body mass index (BMI), as it appears to become less accurate in weight extremes (underweight and particularly overweight/obesity). As recommended by Winter et. al2 and Brown et. al3 the following adjustments are advised:

  • Underweight (BMI < 18.5 kg/m2): Weight uses actual/total body weight (No adjustment)
  • Normal Weight (BMI 18.5 - 22.9): Weight uses ideal body weight (with the range using the actual body weight)
  • Overweight/Obese (BMI ≥ 23): Weight uses adjusted body weight (with the range using ideal body weight).


References:
1Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
2Winter MA, Guhr KN, Berg GM. Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation. Pharmacotherapy. 2012;32(7):604-12.
3Brown DL, Masselink AJ, Lalla CD. Functional range of creatinine clearance for renal drug dosing: a practical solution to the controversy of which weight to use in the Cockcroft-Gault equation. Ann Pharmacother. 2013;47(7-8):1039-44.
 

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This model is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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