Overall model performance:
Internal-external cross-validation by seven different regions was performed to evaluate the performance of the model. Model calibration and discrimination were assessed graphically and by a c-index, respectively. The C-index for the final model was 0.73 (95% CI 0.69-0.77) and the calibration at 5-year overall survival was considered adequate.Cross-validation yield a poled C-index of 0.69 (95% CI 0.65-0.73), with a reasonable calibration across the regions.
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