Survival stratification in patients with advanced renal cell carcinoma (poi - Evidencio
Survival stratification in patients with advanced renal cell carcinoma (point score)
Five prognostic factors for predicting survival were identified and used to categorize patients with metastatic RCC into three risk groups, for which the median survival times were separated by 6 months or more. These risk categories can be used in clinical trial design and interpretation and in patient management. The low long-term survival rate emphasizes the priority of clinical investigation to identify more effective therapy.

Note: In this model, the original predictor coefficients were reduced to points for the sake of simplicity.
Research authors: Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J.
Version: 1.8
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Total points on advanced renal cell carcinoma surival score: points

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Median survival time in the original study population (N=670):
The median time to death in 25% of patients deemed favorable-risk was 20 months, and the 1-, 2-, and 3-year survival rates were 71%, 45%, and 31%, respectively. Fifty-three percent of the patients were in the intermediate-risk group. The median survival time for this group was 10 months, with 1-, 2-, and 3-year survival rates of 42%, 17%, and 7%, respectively. In contrast, the poor-risk group, which comprised 22% of the patients, had a median survival time of 4 months, with 1-, 2-, and 3-year survival rates of 12%, 3%, and 0%. Only one poor-risk patient remained alive at the time of last follow-up. There was a significant difference in the survival profiles of the three risk groups (P < .0001).

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