Hemorrhage after thrombolysis (HAT) score
The hemorrhage after thrombolysis (HAT) score predicts post tissue plasminogen activator (tPA) hemorrhage.
Research authors: Lou M, Safdar A, Mehdiratta M, Kumar S, Schlaug G, Caplan L, Searls D, Selim M.
Details Formula Study characteristics Files & References
★★★
Model author
Model ID
352
Version
1.10
Revision date
2016-04-25
Specialty
MeSH terms
  • Hemorrhage
  • Plasminogen Activator, Tissue-Type
  • Therapeutic Thrombolysis
  • Model type
    Linear model (Calculation)
    Status
    public
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    Formula
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    Condition Formula

    Additional information

    We constructed a five-point scale based on NIH Stroke Scale score, extent of hypodensity on CT scan, serum glucose at baseline, and history of diabetes to predict the risk of hemorrhage after thrombolysis (HAT score). We evaluated the predictive ability of this scale, using c-statistics, in two independent cohorts: the t-PA treated group in the National Institute of Neurological Disorders and Stroke study, and consecutive patients treated with IV t-PA at our institution.

    Two cohorts were used, the NINDS (National Institute of Neurological Disorders and Stroke) with 302 patients, and the original data set from author (n = 98).

    Study Population

    Total population size: 400
    Males: {{ model.numberOfMales }}
    Females: {{ model.numberOfFemales }}

    Continuous characteristics

    Name Mean SD Unit
    Age NINDS cohort 68 11 Years
    Age author cohort 71 17 Years

    Categorical characteristics

    Name Subset / Group Nr. of patients
    Diabetes Mellitus NINDS cohort 63
    Author cohort 15
    Baseline blood glucose >200mg/dl NINDS cohort 63
    Author cohort 15
    Pretreatment NIHSS score NINDS cohort < 15 points 158
    15-19 points 72
    ≥ 20 points 72
    Pretreatment NIHSS score author cohort < 15 points 51
    15-19 points 30
    ≥ 20 points 17
    Presence of visible hypodensity on initial head CT scan NINDS cohort < 1/3 of middle cerebral artery territory 21
    ≥ 1/3 of middle cerebral artery territory 5
    Presence of visible hypodensity on initial head CT scan author cohort < 1/3 of middle cerebral artery territory 20
    ≥ 1/3 of middle cerebral artery territory 3

    Related files

    Total hemorrhage after trombolysis (HAT) score:
    ...
    points

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    Result
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    Total hemorrhage after trombolysis (HAT) score: points

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    Outcome stratification

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    Result interpretation


    Note: 

    The HAT Score can assist emergency and neurology providers to estimate the risk/benefit of tPA in borderline cases. In addition, it can assist in determining which patients need the closest monitoring if tPA is administered.

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    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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