Probability of prostate cancer in Chinese men - Evidencio
Probability of prostate cancer in Chinese men
Prostate health index (PHI) nomogram predicting the probability of prostate cancer in Chinese men with PSA ≤10 ng/mL and normal digital rectal examination (c-index: 0.79).
Autores de la investigación: Zhu Y, Han CT, Zhang GM, Liu F, Ding Q, Xu JF, Vidal AC, Freedland SJ, Ng CF, Ye DW.
Versión: 1.19
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Probability of prostate cancer:

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Información condicional

This nomogram provides an objective and quantifiable estimation of cancer risk and offers useful information for consultation. The decision to perform a prostate biopsy not only depends on prostate carcinoma risk, but also on multiple factors, including the patient’s life expectancy, co-morbidity, and preference.

Model performance:
On internal validation using a 200 bootstrap resampled dataset, the nomogram’s corrected AUC was 0.872. The calibration plot showed good correlation between predicted and actual probability. In a separate validation cohort consisting of 230 patients, the AUC of the nomogram was 0.786 (range, 0.678–0.894).

Clinical relevance: 
Zhu et al (2015) simulated clinical decision making by calculating the consequences of applying different criteria in the validation cohort. PSAD biopsy criteria resulted in unnecessary biopsies in 42.6% of cases and missed 28.6% of cancer cases. Using the PHI-nomogram, the authors were able to significantly reduce the number of unnecessary biopsies. For example, at the cutoff of 5%, unnecessary biopsies were reduced to 27% without missing any additional cancer cases.

Reference: Zhu Y, Han CT, Zhang GM, Liu F, Ding Q, Xu JF, Vidal AC, Freedland SJ, Ng CF, Ye DW. Development and external validation of a prostate health index-based nomogram for predicting prostate cancer. Sci Rep. 2015 16;5:15341.


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Este algoritme se proporciona con fines educativos, formativos e informativos. No debe utilizarse para apoyar la toma de decisiones médicas ni para prestar servicios médicos o de diagnóstico. Lea nuestro disclaimer.

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