INFLUENCE: Five-year locoregional recurrence risk in breast cancer patients
Calculates the 5-year risk for locoregional recurrence (LRR) in breast cancer patient (c-index: 0.71).
Research authors: Annemieke Witteveen, Ingrid M. Vliegen, Gabe S. Sonke, Joost M. Klaase, Maarten J. IJzerman, Sabine Siesling
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  • Oncology
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The five year risk of a locoregional recurrence is:

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How this model should be used: 
This model can be used as an instrument to identify patients with a high 5-year risk of locoregional recurrence (LRR) who might benefit from a less or more intensive follow-up after breast cancer and to aid clinical decision making.

Model performance: 
The probability measure of the predictive ability given as the c-statistic (area under the ROC curve) was 0.71 for the 5-year risk of LRR (95% CI: 0.69-0.73), indicating good discriminating ability. In addition, the model showed good calibration (Figure 1). 

Witteveen A, Vliegen IM, Sonke GS et al. Personalisation of breast cancer follow-up: a time-dependent prognostic nomogram for the estimation of annual risk of locoregional recurrence in early breast cancer patients. Breast Cancer Res Treat. 2015; 152(3): 627–636.


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Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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