ADAPT - Evidencio

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The ADAPT is an algorithm that incorporates Pro-C3 (Elecsys® Pro-C3 assay) to support predictions on the severity of hepatic (i.e. liver) fibrosis in patients showing evidence or signs of metabolic dysfunction-associated steatotic liver disease (MASLD).

Research authors: Daniels SJ, Leeming DJ, Eslam M, Hashem AM, Nielsen MJ, Krag A, Karsdal MA, Grove JI, Guha IN, Kawaguchi T, Torimura T, McLeod D, Akiba J, Kaye P, de Boer B, Aithal GP, Adams LA, George J

Version: 3.0.{{ model.microversion }}

Public
Hepatology
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V-3.0-6094.26.02.20

(01)08720938015298(8012)v3.0(4326)260220(240)6094

Download the User manual and consult the Intended purpose.

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Additional information

Details

Algorithm author

T. A. Hueting

Algorithm ID

6094

Version

3.0.{{ model.microversion }}

Revision date

2026-02-20

Specialty

Hepatology

Algorithm type

Custom calculation ^{(Calculation)}

MeSH terms

Fibrosis, Liver

NAFLD

Liver Steatosis

Cirrhosis, Liver

Status

Public

Formula

Study characteristics

Additional information

The ADAPT was developed within a study cohort with a total of 431 well phenotyped patients with biopsy confirmed NAFLD. The algorithm was first developed by Daniels et al. in 2019. The ADAPT combines Age, Elecsys® Pro-C3, Platelet count, and Diabetes to assist in risk stratification of patients with (signs or evidence of) MASLD (formerly NAFLD/MAFLD) based on the severity of liver fibrosis. The ADAPT is externally validated in many studies and demonstrated better performance in risk stratification of patients with MASLD based on the severity of liver fibrosis compared to the FIB-4 Index.

Study Population

Total population size: 431

Continuous characteristics

Name	Mean	SD	Unit
Age (Derivation cohort) (n=150)	50.85	12.13	Years
PRO-C3 (Derivation cohort) (n=150)	20.92	15.48	ng/mL
Platelet count (Derivation cohort) (n=148)	244.4	73.53	x 10^9/L
Age (Validation cohort) (n=277)	52.9	12.38	Years
PRO-C3 (Validation cohort) (n=279)	19.93	18.04	ng/mL
Platelet count (Validation cohort) (n=270)	229.7	79.49	x 10^9/L

Categorical characteristics

Name	Subset / Group	Nr. of patients
Cohorts	Derivation cohort	150
Cohorts	Validation cohort	281
Diabetic	Derivation cohort	56
Diabetic	Validation cohort	105

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V-3.0-6094.26.02.20

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Study Population

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Categorical characteristics

Supporting Publications

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	Evidencio B.V., Irenesingel 19, 7481 GJ Haaksbergen, The Netherlands
	V-3.0-6094.26.02.20
	(01)08720938015298(8012)v3.0(4326)260220(240)6094
	Download the User manual
	Medical device In vitro diagnostic medical device