Chemotherapy-induced nausea in cancer patients receiving emetogenic chemoth - Evidencio
Chemotherapy-induced nausea in cancer patients receiving emetogenic chemotherapy
Chemotherapy-induced nausea and vomiting (CINV) is presented in over 30% of cancer patients receiving highly/moderately emetogenic chemotherapy (HEC/MEC). The currently recommended antiemetic therapy is merely based on the emetogenic level of chemotherapy, regardless of patient's individual risk factors. This model aims to provide an approach for personalized management of CINV.
Research authors: Hu Z, Liang W, Yang Y, Keefe D, Ma Y, Zhao Y, Xue C, Huang Y, Zhao H, Chen L, Chan A, and Zhang L.
Version: 1.26
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  • Oncology
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Probability chemotherapy-induced nausea in cancer patients:

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How this model should be used: 
This validated nomogram could help the personalized management of chemotherapy-induced nausea and vomiting (CINV) in clinical practice. For those with high risk of CINV, clinicians should consider a modified antiemetic regimen with additional use of these unconventional antiemetic agents.1 Besides, some other actions could be taken to prevent CINV, such as psychological intervention, lifestyle adjustment, or symptoms control on fatigue or anxiety.

Study limitations: 
First, the nomogram only predicts the CINV due to the first cycle of chemotherapy treatment. Dynamic prediction is necessary for effective CINV management, as the probability of its occurrence would increase with the continuation of chemotherapy. Second, predictors and their contribution to CINV may be different in acute phase (<24 hours) and delayed phase (24–120 hours) after chemotherapy. Last, all the patients in the study were from Asian countries, so its applicability should be further investigated in other ethnic populations.

Source: 

  1. Hu Z, Liang W, Yang Y, et al. Personalized estimate of chemotherapy-induced nausea and vomiting: development and external validation of a nomogram in cancer patients receiving highly/moderately emetogenic chemotherapy. Medicine (Baltimore). 2016;95(2):e2476.

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This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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