CLIF-C ACLFs: Acute-on-chronic liver failure mortality - Evidencio
CLIF-C ACLFs: Acute-on-chronic liver failure mortality
Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) is a frequent syndrome (30% prevalence), characterized by acute decompensation of cirrhosis, organ failure(s) and high short-term mortality. This study develops and validates a specific prognostic score for ACLF patients.
Research authors: Rajiv Jalan, Faouzi Saliba, Marco Pavesi, Alex Amoros, Richard Moreau, Pere Ginès, Eric Levesque, Francoi Durand, Paolo Angeli, Paolo Caraceni, Corinna Hopf, Carlo Alessandria, Ezequiel Rodriguez, Pablo Solis-Muñoz, Wim Laleman, Jonel Trebicka, Stefan Zeuzem, Thierry Gustot, Rajeshwar Mookerjee, Laure Elkrief, German Soriano, Joan Cordoba, Filippo Morando, Alexander Gerbes, Banwari Agarwal, Didier Samuel, Mauro Bernardi, Vicente Arroyo
Version: 1.24
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Bilirubin

0
50
mg/dl

Creatinine

0
15
mg/dl

Renal replacement therapy

Use of vasopressors

West-Haven grade for HE

International normalized ratio

0
10
Ratio

Mean arterial pressure

60
220
mmHg

Lung score

Mechanical ventilation

Age

0
100
Years

White bloodcell count (WBC)

0
40
x10^9 cells/L

Mortality calculated over:

Calculated risk of death is: ... %

Set all parameters to calculate prediction.

The CLIF-C ACLFs at ACLF diagnosis is superior to the MELDs and MELD-Nas in predicting mortality. The CLIF-C ACLFs is a clinically relevant, validated scoring system that can be used sequentially to stratify the risk of mortality in ACLF patients.

C-statistics at 28 days is: 0.744 (CI 95%: 0.7020.787)
C-statistics at 90 days is: 0.736 (CI 95%: 0.696 0.776)
C-statistics at 180 days is: 0.723 (CI 95%: 0.683 0.763)
C-statistics at 365 days is: 0.707 (CI 95%: 0.668 0.746)

This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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