CLIF-C ACLFs: Acute-on-chronic liver failure mortality
Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) is a frequent syndrome (30% prevalence), characterized by acute decompensation of cirrhosis, organ failure(s) and high short-term mortality. This study develops and validates a specific prognostic score for ACLF patients.
Research authors: Rajiv Jalan, Faouzi Saliba, Marco Pavesi, Alex Amoros, Richard Moreau, Pere Ginès, Eric Levesque, Francoi Durand, Paolo Angeli, Paolo Caraceni, Corinna Hopf, Carlo Alessandria, Ezequiel Rodriguez, Pablo Solis-Muñoz, Wim Laleman, Jonel Trebicka, Stefan Zeuzem, Thierry Gustot, Rajeshwar Mookerjee, Laure Elkrief, German Soriano, Joan Cordoba, Filippo Morando, Alexander Gerbes, Banwari Agarwal, Didier Samuel, Mauro Bernardi, Vicente Arroyo
Version: 1.24
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Calculated risk of death is: %

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The CLIF-C ACLFs at ACLF diagnosis is superior to the MELDs and MELD-Nas in predicting mortality. The CLIF-C ACLFs is a clinically relevant, validated scoring system that can be used sequentially to stratify the risk of mortality in ACLF patients.

C-statistics at 28 days is: 0.744 (CI 95%: 0.7020.787)
C-statistics at 90 days is: 0.736 (CI 95%: 0.696 0.776)
C-statistics at 180 days is: 0.723 (CI 95%: 0.683 0.763)
C-statistics at 365 days is: 0.707 (CI 95%: 0.668 0.746)

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