NAFLD score: Non-alcoholic fatty liver disease score.
Patients with nonalcoholic fatty liver disease (NAFLD) and advanced liver fibrosis are at the highest risk for progressing to end-stage liver disease. Current model consists and validated a scoring system consisting of routinely measured and readily available clinical and laboratory data to separate NAFLD patients with and without advanced fibrosis.
Research authors: Paul Angulo, Jason M. Hui, Giulio Marchesini, Ellisabetta Bugianesi, Jacob George, Geoffrey C. Farrell, Felicity Enders, Sushma Saksena, Alastair D. Burt, John P. Bida, Keith Lindor, Schuyler O. Sanderson, Marco Lenzi, Leon A. Adams, James Kench, Terry M Therneau, Christopher P. day
Details Custom formula Study characteristics Files & References
Model author
Model ID
Revision date
MeSH terms
  • Fibrosis
  • Liver Fibrosis
  • Liver Disease
  • Liver Disease
  • Fibrosis
  • Non alcoholic Fatty Liver Disease
  • Model type
    Linear model (Calculation)
    No Formula defined yet
    Condition Formula

    Additional information

    A total of 733 patients with well-characterized and liver biopsy–confirmed NAFLD were included in this study. They were untreated, consecutively biopsied patients seen at the Mayo Clinic in Rochester, MN (n = 356); Newcastle, UK (n = 158); Sydney, Australia (n = 123); and Italy (n = 96) during 2000–2003. The study was approved by appropriate regulatory bodies at all centers.

    Study Population

    Total population size: 733
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    Females: {{ model.numberOfFemales }}

    Continuous characteristics

    Name Mean SD Unit
    Age 47.7 13.2 years
    BMI 32.2 6.1 kg/m2
    Waist circumference 101.8 16.6 cm
    Waist-to-hip ratio 0.96 0.07 ratio
    ALT 87 72 U/l
    AST 60 50 U/l
    AST/ALT ratio 0.84 0.83 ratio
    Albumin 4.3 0.5 g/dl
    Billirubin 0.8 0.6 mg/dl
    AST/platelet ratio 0.94 0.9 ratio
    Platelet count 235 84 x10^9/L
    GGT 96 105 U/l
    HOMA 5.53 5.91 HOMA
    Glucose 116 50 mg/dl
    Triglycerides 211 161 mg/dl
    Total cholesterol 209 50 mg/dl
    Biopsy length 187 8.5 mm
    Portal areas 10 4.5 n

    Categorical characteristics

    Name Subset / Group Nr. of patients
    BMI Normal 47
    Overweight 243
    Obese 443
    Diabetes No 514
    Yes 219
    Hyperglycemia No 450
    Yes 283
    Hypertriglyceridemia No 295
    Yes 438
    Low HDL-cholesterol No 361
    Yes 372
    Hypertension No 513
    Yes 220
    Fibrosis stage F0 244
    F1 190
    F2 100
    F3 95
    F4 104

    Related files

    No related files available

    Supporting Publications

    NAFLD score is:

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    NAFLD score is: Points

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    Outcome stratification

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    Conditional information

    Result interpretation

    Fibrosis severity scale:

    • F0 = no fibrosis
    • F1 = mild fibrosis
    • F2 = moderate fibrosis
    • F3 = severe fibrosis
    • F4 = cirrhosis

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    Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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