ELAN-HF Score - Evidencio

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The ELAN-HF is a linear model that predicts 180-day all-cause mortality after discharge in patients hospitalised for Acute Decompensated Heart Failure (ADHF), using demographics, clinical parameters, sodium, serum urea, and NT-proBNP measurement, including reduction in NT-proBNP.

Research authors: Khibar Salah, Wouter E Kok, Luc W Eurlings, Paulo Bettencourt, Joana M Pimenta, Marco Metra, Antoni Bayes-Genis, Valerio Verdiani, Luca Bettari, Valentina Lazzarini, Peter Damman, Jan G Tijssen, Yigal M Pinto

Version: 2.0

Public
Cardiology
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V-2.0-9969.25.10.01

(01)08720938015304(8012)v2.0(4326)251001(240)9969

Download the User manual and consult the Intended purpose.

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Conditional information

The ELAN-HF Score is used to estimate 180-day all-cause mortality post-discharge. It was developed by Salah et al. in 2013, and externally validated by Salah et al. in 2019.

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Details

Algorithm author

Evidencio

Algorithm ID

9969

Version

2.0

Revision date

2025-10-01

Specialty

Cardiology

Algorithm type

Custom calculation (Conditional)

MeSH terms

Heart Failure

Status

Public

Condition	Formula

Study characteristics

Additional information

The derivation study used a combined cohort from 7 different studies with a total of 1301 patients for Cox regression and subsequently derived a linear scoring tool. A validation cohort of 325 patients was used to validate the scoring tool. Different in- and exclusion criteria were used in the different studies included in the development of the ELAN-HF. As such, not all patient groups were equally represented. Therefore, it should be noted that many (but not all) studies used for the development of the ELAN-HF Score excluded patients with ACS, or patients with a certain degree of renal dysfunction or dialysis.

Study Population

Total population size: 1301

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Females: {{ model.numberOfFemales }}

Continuous characteristics

Name	Mean	SD	Unit
SBP at admission	133	31.9	mm Hg
DBP at admission	81	20.3	mm Hg
Heart rate at admission	93	24.8	bpm
Haemoglobin at admission	126.4	20.5	g/L
Haemoglobin at discharge	128.0	19.9	g/L
Serum urea at admission	12.6	7.8	mmol/L
Serum urea at discharge	13.7	8.1	mmol/L
eGFR at admission	56.9	32.8	mL/min/1.73 m², calculated with MDRD equation
eGFR at discharge	56.9	42.0	mL/min/1.73 m², calculated with MDRD equation

Name	Q1	Median	Q3	Unit
Age	64	74	80	Years
NT-proBNP at admission	3057	6447	12632	pg/mL
NT-proBNP at discharge	1419	3252	7291	pg/mL
cTnT at admission	0.01	0.03	0.10	μg/L
Admission duration	6	9	14	Days

Categorical characteristics

Name	Subset / Group	Nr. of patients
Age	≥ 75	607
History	DM	422
History	COPD	209
History	Hypertension	661
Admission variables	JVP Distended at admission	635
Admission variables	Pulmonary rales at admission	821
Admission variables	peripheral oedema at admission	674
Admission variables	Atrial fibrillation at admission	513
LVEF	Preserved (≥45%)	327
LVEF	Mild-moderate (25–44%)	514
LVEF	Severe (<25%)	324
NYHA class at discharge	III	212
NYHA class at discharge	IV	4
Discharge medication	Diuretics	1156
Discharge medication	ACE-inhibitor	806
Discharge medication	β-blocker	685

Supporting Publications

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Extra Information

	Evidencio B.V., Irenesingel 19, 7481 GJ Haaksbergen, The Netherlands
	V-2.0-9969.25.10.01
	(01)08720938015304(8012)v2.0(4326)251001(240)9969
	Download the User manual
	Medical device In vitro diagnostic medical device

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This algorithm has been certified as a medical device

V-2.0-9969.25.10.01

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The result of the ELAN-HF Score is points.

Conditional information

Details

Study characteristics

Additional information

Study Population

Continuous characteristics

Categorical characteristics

Supporting Publications

Related files

This algorithm has been certified as a medical device

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