eGFR 2009 CKD-EPI creatinine equation (without race)

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The CKD-EPI eGFRcr calculator is intended to be used by professional users who are capable of operating the device and interpreting its results. It can be used to estimate the Glomerular Filtration Rate in patients to assess kidney functioning.

The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equations were developed in an effort to create a more precise formula to estimate glomerular filtrate rate (GFR) from serum creatinine, age, sex, and originally race. The CKD-EPI released their original equations in 2009, which included race as a variable. In 2021, they used the same data to derive a new equation that does not include race as an explanatory variable.

This version regards the 2009 equation, excluding race as an explanatory variable.

Research authors: Lesley A. Inker, M.D., Nwamaka D. Eneanya, M.D., M.P.H., Josef Coresh, M.D., Ph.D., Hocine Tighiouart, M.S., Dan Wang, M.S., Yingying Sang, M.S., Deidra C. Crews, M.D., Alessandro Doria, M.D., Ph.D., M.P.H., Michelle M. Estrella, M.D., M.H.S., Marc Froissart, M.D., Ph.D., Morgan E. Grams, M.D., M.H.S., Ph.D., Tom Greene, Ph.D., Anders Grubb, M.D., Ph.D., Vilmundur Gudnason, M.D., Ph.D., Orlando M. Gutiérrez, M.D., Roberto Kalil, M.D., Amy B. Karger, M.D., Ph.D., Michael Mauer, M.D., Gerjan Navis, M.D., Ph.D., Robert G. Nelson, M.D., Ph.D., Emilio D. Poggio, M.D., Roger Rodby, M.D., Peter Rossing, M.D., D.M.Sc., Andrew D. Rule, M.D., Elizabeth Selvin, Ph.D., M.P.H., Jesse C. Seegmiller, Ph.D., Michael G. Shlipak, M.D., M.P.H., Vicente E. Torres, M.D., Ph.D., Wei Yang, Ph.D., Shoshana H. Ballew, Ph.D., Sara J. Couture, M.P.H., Neil R. Powe, M.D., M.P.H., M.B.A., Andrew S. Levey, M.D.

Version: 2.0

Public
Nephrology
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V-2.0-9984.26.02.26

(01)08720938015250(8012)v2.0(4326)260226(240)9984

Download the User manual and consult the Intended purpose.

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Estimated GFR:

mL/min/1.73m^2

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Estimated GFR: mL/min/1.73m^2

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The eGFR is an estimation of the Glomerular Filtration Rate, estimated through serum Creatinine concentrations. Generally, normal GFR values lie between 90 and 120 mL/min/1.73m^2. A GFR between 60 and 90 may point to early stage kidney disease A GFR between 15 and 60 is indicative of kidney disease a GFR below 15 is a sign of kidney failure.

One of the disadvantages of the CKD-EPI eGFRcr calculator is that it only accounts for Age and Sex (and Race, in the 2009 equations) without taking into account body shape. As Creatinine is produced by muscle tissue, production levels differ between different patients, as people of the same age and gender may have drastically different amounts of muscle tissue, which influences eGFR calculation.

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Calculations alone should never dictate patient care, and are no substitute for professional judgement. See our full disclaimer.

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Additional information

Details

Algorithm author

Evidencio

Algorithm ID

9984

Version

2.0.{{ model.microversion }}

Revision date

2026-02-26

Specialty

Nephrology

Algorithm type

Custom calculation (Conditional)

MeSH terms

Kidney

Creatinine

Glomerular Filtration Rate

Status

Public

Condition	Formula

Study characteristics

Additional information

The CKD-EPI eGFRcr equations were developed in an effort to create a more precise formula to estimate glomerular filtrate rate (GFR) from serum creatinine and other readily available clinical parameters, especially at when actual GFR is >60 mL/min per 1.73m². The original equations were derived in 2009 and included Race as an explanatory variable in model derivation. In 2021, the CKD-EPI derived a new set of equations using the same data-set, without using Race as a variable. Evidencio's version of the CKD-EPI eGFRcr calculator includes three versions of the equations.

The original 2009 equations derived using race as an explanatory variable in addition to Age, Sex and serum Creatinine. (eGFR 2009 CKD-EPI eGFR creatinine equation)
The 2009 equations, derived using Race, Age, Sex and serum Creatinine as explanatory variables, without including the race variable in the calculation. (eGFR 2009 CKD-EPI eGFR creatinine equation (without race))
The 2021 equations, derived without using race as an explanatory variable, using only Age and Sex in addition to serum Creatinine as explanatory variables. (eGFR 2021 CKD-EPI eGFR creatinine equation)

New eGFR equations that incorporate creatinine and cystatin C but omit race were more accurate and led to smaller differences between Black participants and non-Black participants than new equations without race with either creatinine or cystatin C alone in the 2021 study.

Study Population

Total population size: 8254

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Females: {{ model.numberOfFemales }}

Continuous characteristics

Name	Mean	SD	Unit
Age	47	14.8	Year
BMI	28.2	6.1	kg/m2
Measured GFR	67.6	39.6	ml/min/1.73m^2
Creatinine	1.66	1.16	mg/dl

Categorical characteristics

Name	Subset / Group	Nr. of patients
Age	<40yr	2921
Age	40-65 yr	4309
Age	>65 yr	1024
BMI	<20	285
BMI	20 to <25	2446
BMI	25 to <30	2923
BMI	≥30	2600
Diabetes (data available for 3616 patients)	Yes	2406
Kidney-donor candidate	Yes	1030
Measured GFR Category	<30 ml/min/1.73 m2	1722
Measured GFR Category	30 to <60 ml/min/1.73 m2	2334
Measured GFR Category	60 to <90 ml/min/1.73 m2	1669
Measured GFR Category	≥90 ml/min/1.73 m2	2529

Supporting Publications

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Extra Information

	Evidencio B.V., Irenesingel 19, 7481 GJ Haaksbergen, The Netherlands
	V-2.0-9984.26.02.26
	(01)08720938015250(8012)v2.0(4326)260226(240)9984
	Download the User manual
	Medical device In vitro diagnostic medical device

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V-2.0-9984.26.02.26

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Disclaimer: Calculations alone should never dictate patient care, and are no substitute for professional judgement.

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Estimated GFR: mL/min/1.73m^2

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Study characteristics

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Study Population

Continuous characteristics

Categorical characteristics

Supporting Publications

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