Evidencio validations - Evidencio
Validation cohort from Cancer Hospital of Shantou University Medical College (China)
Study population:
This external validation study enrolled a consecutive series of 324 patients with primary invasive early breast carcinoma treated at the Breast Center, Cancer Hospital of Shantou University Medical College from May 2014 to November 2015.

Inclusion criteria:
The inclusion criteria were female patients with early invasive breast cancer (TNM stage according to the 7th edition of the AJCC Cancer Staging Manual: T1-3 and N0-1), having positive axillary ultrasound (defined as at least one lymph node visible by ultrasound), and receiving a successful SLNB or ALND.

Exclusion criteria:
Patients with local advanced disease (TNM stage according to the 7th edition of the AJCC Cancer Staging Manual: T4 or N2-3), neo-adjuvant treatment, or bilateral breast cancer were excluded.
auteurs de la recherche: Si-Qi

Discrimination

Rangs inclus 231
Indice C 0.873 | 95% CI: 0.8279 - 0.9187 ROC
Score du Brier 0.143
Score de Brier gradué 0.418

Tracé de la classification

Calibrage

Coefficient de régression 1.063
Intercept -0.067
Hosmer-Lemeshow GOF 0.395
 

Tracé d'étalonnage

Histogramme

Courbe de décision

Comparaison
Population originale de l'étude : 322
Population de l'étude de validation : 234

Caractéristiques catégorielles

Nom Sous-ensemble / Groupe Nombre de patients Validation Valeur P
Patient age ≤35 years 25 12 0.2331
>35 years 297 222
Menopausal status Premenopausal 182 118 0.1683
Postmenopausal 140 116
Clinical tumor size by T-class T1 74 44 0.2757
T2 223 169
T3 22 21
Unknown 3 0
Tumor locations Upper outer quadrant 152 118 0.4563
Lower outer quadrant 42 25
Upper inner quadrant 51 43
Lower inner quardant 15 14
Central 62 34
Histological grade Grade I 49 24 0.0073
Grade II 104 95
Grade III 154 113
Unknown 15 2
Histological type Ductal 294 220 0.5502
Lobular 10 5
Other 18 9
Estrogen receptor status Negative 119 78 0.0051
1+ 22 25
2+ 57 21
3+ 124 110
Progesteron receptor status Negative 132 106 0.6472
1+ 38 30
2+ 63 39
3+ 89 59
HER2neu receptor Negative 223 153 0.3591
Positive 99 81
Ki-67 ≤14 51 25 0.2384
>14 268 207
Unknown 3 2
P53 Negative 117 38 Non disponible
Positive 197 191
Unknown 8 5
VEGF-C Negative 75 43 0.1957
Positive 222 165
Unknown 25 26
Molecular subtype Luminal A 173 119 0.6194
Luminal B 44 38
HER-2 enriched 51 43
Triple negative 54 34
Lymph node detected by ultrasound 1 123 68 0.0298
≥2 199 166
Absence of medulla Yes 87 69 0.5664
No 235 165
Absence of hilum Yes 126 128 0.0003
No 196 106
Lymph node metastases Yes 163 133 0.1684
No 159 101

Caractéristiques continues

Nom LI Q1 Médiane Q3 LS Unité
Original Validation Tumor size
23
24
30
30
40
40

mm Entrée invalide
Original Validation Transverse diameter
10
11
13
15
17
18

mm Entrée invalide
Original Validation Longitudinal diameter
5
5.75
7
7
9
10

mm Entrée invalide
Original Validation Cortical thickness
3
3
4
4
6
7

mm Entrée invalide
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