Validation cohort from Cancer Hospital of Shantou University Medical College (China)
Study population:
This external validation study enrolled a consecutive series of 324 patients with primary invasive early breast carcinoma treated at the Breast Center, Cancer Hospital of Shantou University Medical College from May 2014 to November 2015.

Inclusion criteria:
The inclusion criteria were female patients with early invasive breast cancer (TNM stage according to the 7th edition of the AJCC Cancer Staging Manual: T1-3 and N0-1), having positive axillary ultrasound (defined as at least one lymph node visible by ultrasound), and receiving a successful SLNB or ALND.

Exclusion criteria:
Patients with local advanced disease (TNM stage according to the 7th edition of the AJCC Cancer Staging Manual: T4 or N2-3), neo-adjuvant treatment, or bilateral breast cancer were excluded.
Validation study authors: Si-Qi
Validation author
Revision date
2018-07-12
MeSH terms
  • Breast Cancer
  • Lymph Nodes
  • Metastasis
  • Ultrasound Imaging
  • Nomograms
  • Status
    public
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    Details

    Related files

    Discrimination

    C-index: 0.8733 | 95% CI: 0.8279 - 0.9187
    ROC Plot:

    Calibration

    Regression coefficient: 1.0629 | Intercept: -0.07
    Calibration plot:

    Histogram

    Rows included: 231
    Comparison
    Original study population: 322
    Validation study population: 234

    Categorical characteristics

    Name Subset / Group Nr. of patients Validation P-Value
    Patient age ≤35 years 25 12 0.2331
    >35 years 297 222
    Menopausal status Premenopausal 182 118 0.1683
    Postmenopausal 140 116
    Clinical tumor size by T-class T1 74 44 0.2757
    T2 223 169
    T3 22 21
    Unknown 3 0
    Tumor locations Upper outer quadrant 152 118 0.4563
    Lower outer quadrant 42 25
    Upper inner quadrant 51 43
    Lower inner quardant 15 14
    Central 62 34
    Histological grade Grade I 49 24 0.0073
    Grade II 104 95
    Grade III 154 113
    Unknown 15 2
    Histological type Ductal 294 220 0.5502
    Lobular 10 5
    Other 18 9
    Estrogen receptor status Negative 119 78 0.0051
    1+ 22 25
    2+ 57 21
    3+ 124 110
    Progesteron receptor status Negative 132 106 0.6472
    1+ 38 30
    2+ 63 39
    3+ 89 59
    HER2neu receptor Negative 223 153 0.3591
    Positive 99 81
    Ki-67 ≤14 51 25 0.2384
    >14 268 207
    Unknown 3 2
    P53 Negative 117 38 Not available
    Positive 197 191
    Unknown 8 5
    VEGF-C Negative 75 43 0.1957
    Positive 222 165
    Unknown 25 26
    Molecular subtype Luminal A 173 119 0.6194
    Luminal B 44 38
    HER-2 enriched 51 43
    Triple negative 54 34
    Lymph node detected by ultrasound 1 123 68 0.0298
    ≥2 199 166
    Absence of medulla Yes 87 69 0.5664
    No 235 165
    Absence of hilum Yes 126 128 0.0003
    No 196 106
    Lymph node metastases Yes 163 133 0.1684
    No 159 101

    Continuous characteristics

    Name LL Q1 Median Q3 UL Unit
    Original
    Validation
    Tumor size
    23
    24
    30
    30
    40
    40

    mm Invalid Input
    Original
    Validation
    Transverse diameter
    10
    11
    13
    15
    17
    18

    mm Invalid Input
    Original
    Validation
    Longitudinal diameter
    5
    5.75
    7
    7
    9
    10

    mm Invalid Input
    Original
    Validation
    Cortical thickness
    3
    3
    4
    4
    6
    7

    mm Invalid Input
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