Atherogenic Index of Plasma (AIP)
In individuals with type 2 diabetes, metabolic syndrome, and the combined dyslipidemia, cardiovascular risk is increased by a clustering of risk factors such as abdominal obesity, impaired fasting glucose, increased blood pressure, low HDL-cholesterol (HDL-C), increased triglycerides (TGs), and an increase in small, dense LDL particles. The current increase in the incidence of type 2 diabetes in the population perhaps poses the most urgent cardiovascular risk. Although insulin resistance is crucial to the pathogenesis of the disease, the associated atherogenic lipoprotein phenotype considerably enhances the risk. Hence there is an ongoing intense search for a medication capable of modifying the atherogenic lipid profile as well as lowering glucose. Medications of the thiazolidinedione class traditionally used for glycemic control in patients with type 2 diabetes seem to hold promise in this respect.
Research authors: Milada Dobiasova, Jiri Frohlich
Version: 1.8
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  • Clinical pharmacology
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The AIP is:

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The AIP is strongly correlated with FERHDL. And is directly related to the risk of atherosclerosis. 

Outcomes are classified as follows:
Low Risk: AIP < 0.11
Intermediate Risk: AIP = 0.11-0.21
High Risk: AIP > 0.21.

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