The 2018 Briganti nomogram: the probability of lymph node invasion (LNI) for patients diagnosed with MRI-targeted and systematic biopsies
The current model predicts the probability of pelvic lymph node involvement for patients with local Clinically Localized Prostate Cancer Diagnosed with Magnetic Resonance Imaging-targeted and Systematic Biopsies

The current model is applicable exclusively to men with a positive MRI-targeted biopsy with concomitant systematic biopsy, as currently indicated by guidelines. Moreover, the risk of LNI should not be estimated using this model for individuals who were diagnosed via systematic biopsy with a negative MRI-targeted biopsy. For these patients, predictive tools developed using data for men diagnosed with systematic biopsy such as the Briganti 2012, Briganti 2017, and MSKCC nomograms are more suitable.
Research authors: Giorgio Gandaglia, Guillaume Ploussard, Massimo Valerio, Agostino Mattei, Cristian Friori, Nicola Fossati, Armando Stabile, Jean-Baptiste Beauval, Bernard Malavaud, Mathieu Roumiguié, Daniele Robesti, Paolo Dell'Oglio, Marco Moschini, Stefania Zamboni, Arnas Rakauskas, Francesco De Cobelli, Francesco Porpiglia, Francesco Montorsi, Alberto Briganti
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The calculated risk of Lymph Node Involvement is:

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Adoption of this model using a 7% cutoff would avoid approximately 60% of ePLND procedures at the cost of missing only 1.6% of LNI cases.

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